Features

Mediterranean Diet !

Gaming Addiction !

Exercise Linked BP !

Skin Pigmentation !

Anti-Cancer Drug !

Delivery Method & Incontinence !

 New Products of SQUARE Pharmaceuticals Ltd.

EDITORIAL TEAM

OMAR AKRAMUR RAB

MBBS, FCGP, FIAGP,

P G Dip. Business Management

MAHFUZUR RAHMAN

MBBS, MBA

Rubyeat Adnan

MBBS, MPH

EDITORIAL

Dear Doctor,

Welcome to healthcare bulletin "e- SQUARE" !

This time, we have focused on some interesting features like -
"Mediterranean Diet !", "Gaming Addiction !", "Exercise Linked BP !", "Skin Pigmentation !",  "Anti-Cancer Drug !", "Delivery Method & Incontinence !".

In our regular feature, we have some products information of SQUARE Pharmaceuticals Ltd. as well.

Please send your feedback !  We always value your comments !

On behalf of the management of SQUARE, we wish you all a very happy, healthy and prosperous life.

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Yours sincerely,

Editorial Team

Reply Mode      : e-square@squaregroup.com

The views expressed in this publication do not necessarily reflect those of its editor or SQUARE Pharmaceuticals Ltd.

                           Exercise may be as effective as prescribed drugs to lower high blood pressure

Exercise may be as effective as prescribed drugs to lower high blood pressure, suggests a pooled analysis of the available data. But there are no direct head to head comparative trials of exercise and blood pressure lowering drugs, and the numbers of participants in some of the included studies were relatively small, caution the researchers. While promising, the findings shouldn't persuade patients to ditch their blood pressure lowering drugs in favor of an exercise regimen just yet, although patients might want to boost their physical activity levels, advises the lead study author in a linked podcast. Exercise can lower systolic blood pressure -- the amount of pressure in the arteries when the heart is beating and expressed as the top number in any blood pressure reading. But what isn't clear is how exercise compares with blood pressure lowering drugs, of which there are several types, as no direct head to head clinical trials have been carried out. Three sets of analyses were done: all types of exercise compared with all classes of blood pressure lowering drugs; different types of exercise compared with different types of drug; and different intensities of exercise compared with different drug doses. And finally, these analyses were repeated, but in a group of exercise trials that included only participants with high blood pressure, as most of these trials were of young healthy participants with normal blood pressure. The results showed that blood pressure was lower in people treated with drugs than in those following structured exercise programs. Researchers recommend that physicians can start prescribing exercise to their patients, but they also need to be cognizant of the resource implications and ensure that the patients that have been referred to exercise interventions can adhere to them and so really derive benefit.

SOURCE: HealthDay News, December 2018

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                                 Scientists to produce anti-cancer drugs in yeast

Nature is so complex that natural molecules used for i.e. cancer treatment still can't be produced by chemical synthesis. Today, major chemical and pharmaceutical companies harvest large amounts of rare plants and seeds in order to extract valuable substances. But the production methods based on extracts from natural resources are environmentally damaging and often give rise to extensive piles of chemical waste. In addition, there is a great danger that these rare plants will go extinct. The need to find new and more sustainable production methods for these types of medicines has grown since the UN recently adopted new regulations to protect biodiversity and raw materials in third world countries. In many cases, these very complex plant chemicals can't be synthesized chemically like 'normal' pharmaceuticals -- it simply has to be a bio-catalytic process. The aim of the research project is to provide the pharmaceutical industry with an alternative production route using the cellular workhorse baker's yeast. To start with, the researchers want to map the so-called biosynthetic pathways of the rare plant Rauvolfia serpentina with the common name Indian snakeroot. From traditional Chinese medicine, it is known that Indian snakeroot produces molecules with anticancer effect. However, manufacturing the valuable compounds outside the plant is still not possible, because the biosynthetic pathways are unknown. In short, a biosynthetic pathway is a number of specific genes that code for enzymes, which synthesize a bio-molecule within the cell. Knowing the genetic "route" of the product, makes it possible to move the genes into, for instance, baker's yeast. The goal is to insert the genes into yeast cells that will act as biological cell factories capable of producing large amounts of these specific therapeutic substances.

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                                          Delivery method associated with pelvic floor disorders after childbirth

Vaginal childbirth substantially increases the probability of developing a pelvic floor disorder later in life of a woman. Researchers results of a 10-year study showing that some delivery modes, including spontaneous vaginal delivery, are associated with higher risk of some types of pelvic floor disorders. This study considered a woman's risk of developing one of four pelvic floor disorders: stress urinary incontinence, overactive bladder, anal incontinence and pelvic organ prolapse. The research team enrolled 1,528 women within five to 10 years of their first birth. These women were followed annually for up to nine years. Of the women, 778 delivered all of their children via cesarean birth, 565 had at least one spontaneous vaginal delivery and 185 had at least one delivery involving forceps or vacuum-assistance, also called operative vaginal delivery. The median age at enrollment was 38.3 -- the youngest study participant at enrollment was 22.7 years old and the oldest participant at the end of the study was age 61.7. In all, the researchers found that cesarean delivery substantially reduced the risk of pelvic floor disorders, most notably pelvic organ prolapse, while operative delivery increased the risk. And for pelvic organ prolapse, the magnitude of these differences grew over time. The researchers also found that a large percentage of new cases of urinary and bowel incontinence developed in the first five years after delivery, while pelvic organ prolapse tended to develop many more years after childbirth. A third discovery was that the genital hiatus size is significantly associated with all pelvic floor disorders but most significantly with pelvic organ prolapse. This suggests that the genital hiatus size is a marker that might identify women at high risk of developing pelvic floor disorders with aging.

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